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Explore published reflexology research without the academic fog. Each paper is organized by study design and evidence strength, with plain-language context where available.
Effectiveness of manual interventions on overall symptoms, pain and quality of life in patients with chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis
The systematic review and meta-analysis aim to thoroughly assess the efficacy of manual interventions like massage therapy, reflexology, and acupressure techniques in relation to overall symptoms, pain, and quality of life (QOL) in patients suffering from CIPN. A total of eight Chinese and English databases were searched, including PubMed, Embase, Cochrane Library, Web of Science, CINAHL, ProQuest, China National Knowledge Infrastructure, and Wan Fang Database. The searching lasted from the establishment of each database to July 2025. The study aims to include randomized controlled trials (RCTs) and quasi-experimental studies. The risk of bias was assessed using the Cochrane risk of bias tool. The primary outcome measures were symptoms of CIPN, pain, and QOL. Standard Deviation (SMD) and 95% CI were calculated in a random-effects model. This study was registered on the International Prospective Register of Systematic Reviews (PROSPERO, CRD420251112391). In total, 11 RCTs with a total of 646 patients were included. The meta-analysis showed that manual interventions may improve primary outcomes, including quality of life (SMD = 1.05; 95% CI = 0.60, 1.50; P 2 > 90%), which may be related to the limited number of existing studies and differences in intervention details. Low- to very low-certainty evidence suggests that manual interventions may reduce core symptoms and pain associated with CIPN, and potentially improve sleep quality and quality of life. However, due to high heterogeneity and risk of bias, these findings should be interpreted with caution.
Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
2026
Mind-Body Interventions for People With Cancer: Evidence, Innovation, and Implementation
Many people with cancer (PWC) continue to experience persistent biopsychosocial and existential challenges across the cancer care continuum. Symptoms such as anxiety, depression, cancer-related fatigue and pain, sleep disturbance, fear of cancer recurrence, cognitive impairment, and reduced quality of life remain highly prevalent during and after treatment, underscoring the need for interventions that address both psychological and physiological dimensions of distress. Mind-body interventions encompass a diverse group of practices that explicitly target the bidirectional relationship between mental and physical processes and are increasingly incorporated into integrative oncology as adjuncts to standard care. This narrative review synthesizes current evidence on mind-body interventions for improving biopsychosocial outcomes in adult PWC. We review guideline-recommended interventions including mindfulness-based interventions, yoga, tai chi and qigong, relaxation therapies, hypnosis, music therapy, acupuncture, acupressure, massage, reflexology, and aromatherapy; as well as emerging modalities such as psychedelic-assisted therapy, biofield therapies, nature-based interventions, and mindfulness-based approaches for sexual dysfunction. For each intervention, we summarize target symptoms, treatment-phase considerations, and the quality and limitations of the supporting evidence. Finally, we discuss future directions with an emphasis on improving methodological rigor, elucidating mechanisms of action, expanding implementation and access, and extending research across diverse populations and all stages of cancer care, including survivorship and end-of-life contexts.
Seminars in radiation oncology
2026
Effect of Reflexology on Menopausal Problems and Quality of Life: A Scoping Review
Menopause is a natural life stage marked by hormonal shifts that often affect women's well-being. Reflexology, a safe and non-pharmacological therapy, may help support wellness during this transition. To present an overview of the literature on the effect of reflexology on menopausal problems and quality of life. The review followed the Arksey and O'Malley (2005) scoping review framework. A comprehensive search was conducted in PubMed (MEDLINE), SCOPUS, CINAHL, and Web of Science using combinations of terms related to perimenopause/menopause, women, reflexology (zone therapy, foot/palm massage), and outcomes such as sleep, fatigue, stress, vasomotor and perimenopausal symptoms, depression, physiological parameters, and health-related quality of life. Article screening and reporting adhered to PRISMA-ScR guidelines. Based on the inclusion criteria adopted, 11 articles were included in the scoping review. Among them, three explored the impact of reflexology on menopausal symptoms, two assessed its effectiveness in reducing depression, and another two investigated its influence on both menopausal symptoms and quality of life. One study evaluated its effect on menopausal symptoms and cortisol levels, one examined the outcomes related to sleep quality and fatigue, another focused on sleep, and one investigated quality of life. Of these studies, six were randomized controlled trials, three employed a quasi-experimental design, and two utilized a pre- and post-test control group design. Research on reflexology among menopausal women shows promising benefits, including reductions in menopausal symptoms, fatigue, depression, and sleep disturbances, and improvement in the overall quality of life. Further rigorous and controlled research is necessary to support the evidence before reflexology can be endorsed as a routine clinical approach for managing menopausal symptoms and enhancing women's quality of life. menopausal symptoms, depression, fatigue, sleep, quality of lif
Advances in mind-body medicine
2026
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